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Liposarcoma is a relatively uncommon type of cancerous tumor that develops in fatty tissues. Usually, the cancer begins as an overgrowth of cells deep within the abdomen or around the muscles in the upper leg, behind the knee or in the upper arm. However, it can form in fat cells anywhere in the body.

Advanced heart failure (also referred to as end-stage heart failure) is a type of heart failure in the final, most serious stage. Heart failure is a progressive condition that worsens over time, with the heart gradually pumping less and less blood, so symptoms will generally become more severe as the condition moves into this advanced stage.